Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been considered one of Missouri’s finest bed and breakfast establishments.
Having recently undergone an extensive year-long renovation, Proprietors, Susan O’Donnell and Patrick Fahey, along with Innkeeper, Jean Marie Rozier-Sellberg, are thrilled to re-open the Main Street Inn B&B and welcome our guests to what we hope will be a truly wonderful experience.
Located in the heart of Sainte Genevieve’s Historic District, and surrounded by beautiful wine country, we are just a short one-hour drive from both St. Louis and Cape Girardeau, five hours from Chicago and just a little over four hours from Nashville.
If you are looking for a relaxing and peaceful getaway, the Main Street Inn B&B is the perfect destination.
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